“Curry” is a general term used for a combination of spices to create a specific flavor used in cooking. It usually contains turmeric, cumin, coriander, fenugreek, and red pepper. The Tumeric is what gives curry its distinctive yellow coloring, and is a plant from the ginger family. It contains a compound called “Curcumin” which according to this article has been found to kill oesophageal cancer cells through a different form of death than we have seen cells die before. Cells self-destruct or “commit suicide” through a process called apoptosis. But Curcumin did not cause a cell-suicide, it actually killed them.
BREAKTHROUGH.
BREAKTHROUGH.
Below you can read the abstract of the actual research article coming out of Ireland, to be published in the British Journal of Cancer November 2009. The conclusion sums it all up, “Curcumin …represents a promising anticancer agent for prevention and treatment of oesophageal cancer.”
Curcumin induces apoptosis-independent death in oesophageal cancer cells.
O'Sullivan-Coyne G, O'Sullivan GC, O'Donovan TR, Piwocka K, McKenna SL.
Br J Cancer. 2009 Nov 3;101(9):1585-95. Epub 2009 Oct 6.
Leslie C. Quick Laboratory, Cork Cancer Research Centre, BioSciences Institute, University College Cork and Mercy University Hospital, Cork, Ireland.
Background: Oesophageal cancer incidence is increasing and survival rates remain extremely poor. Natural agents with potential for chemoprevention include the phytochemical curcumin (diferuloylmethane). We have examined the effects of curcumin on a panel of oesophageal cancer cell lines.Methods:MTT (3-(4,5-dimethyldiazol-2-yl)-2,5 diphenyl tetrazolium bromide) assays and propidium iodide staining were used to assess viability and DNA content, respectively. Mitotic catastrophe (MC), apoptosis and autophagy were defined by both morphological criteria and markers such as MPM-2, caspase 3 cleavage and monodansylcadaverine (MDC) staining. Cyclin B and poly-ubiquitinated proteins were assessed by western blotting.
Results: Curcumin treatment reduces viability of all cell lines within 24 h of treatment in a 5-50 muM range. Cytotoxicity is associated with accumulation in G2/M cell-cycle phases and distinct chromatin morphology, consistent with MC. Caspase-3 activation was detected in two out of four cell lines, but was a minor event. The addition of a caspase inhibitor zVAD had a marginal or no effect on cell viability, indicating predominance of a non-apoptotic form of cell death. In two cell lines, features of both MC and autophagy were apparent. Curcumin-responsive cells were found to accumulate poly-ubiquitinated proteins and cyclin B, consistent with a disturbance of the ubiquitin-proteasome system. This effect on a key cell-cycle checkpoint regulator may be responsible for the mitotic disturbances and consequent cytotoxicity of this drug.
Conclusion: Curcumin can induce cell death by a mechanism that is not reliant on apoptosis induction, and thus represents a promising anticancer agent for prevention and treatment of oesophageal cancer.
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Curried Chicken Breasts
2 pounds boneless, skinless chicken breasts
½ cup plain nonfat yogurt
3 Tablespoons lemon juice
1 Tablespoon low-sodium soy sauce
2 teaspoons curry powder
** Marinate for at least 30 minutes before baking**
1) Preheat oven to 375 degrees F.
2) Combine yogurt, lemon juice, soy sauce and curry.
3) Pour over chicken and let sit at room temperature 30 minutes or in refrigerator for several hours.
4) Bake at 375 degrees F for 40 minutes or until chicken meat turns white.
Serves 6. Calories 180; protein 36 g; fat 2 g; carbohydrate 3 g; fiber 0 g; sodium 210 mg
Blessings,
Ashley
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